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[16] Glutathione-peroxidase depletes the serum levels and cellular levels of glutathione

Glutathione benefits for skin include improved brightness, more even skin tone, reduced dullness, and support in managing pigmentation

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

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Several mutations have been described [21, 22, 25, 26, 29, 3133]

Current evidence is more supportive of using biweekly doses as a maintenance strategy only