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In the LEADER trial, over 9,340 patients with type 2 diabetes and high cardiovascular disease risk underwent randomization to liraglutide or placebo and were followed for a median of 3.8 years resulting in a 13% risk reduction in a combined endpoint of death from cardiovascular cause, nonfatal myocardial infarction, or nonfatal stroke [46]

While such drugs began life as treatments for type 2 diabetes, once the US FDA approved Wegovy for weight loss, sales ballooned and supplies strained, leading to many providers upping their Ozempic stock

When asked about potential mechanisms by which semaglutide itself and not just the weight loss it causes could do harm, Drucker said, Its possible [it] does have effects on, for example, placental blood flow or formation of the placenta