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The idea of combining them stems from their distinct yet complementary mechanisms of action

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The weight-loss results continued to the 48-week endpoint, with the 12 mg retatrutide group achieving a mean weight reduction of -24.2%, while the placebo group only saw a -2.1% change

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By targeting GLP-1, GIP, and glucagon receptors, researchers are exploring whether multi-pathway therapy can produce deeper metabolic effects than earlier medications

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