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17 Administration of GLP-1 or the GLP-1R agonist, exendin-4 (Ex4), into the CNS reduces food intake and body weight, actions historically attributed to the hypothalamic and brainstem GLP-1R-expressing targets
The primary mechanism involves stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, and slowing gastric emptying
When gut bacteria ferment fiber and produce butyrate, it signals specialized cells in the gut lining to release GLP-1, a hormone involved in appetite and blood sugar control
Here are some suggestions for managing the common side effects
However, more human studies are needed to confirm these findings (7)
Exercise and Stress Management Frequent exercise and effective stress management strategies can likewise play a pivotal role in sustaining healthy glutathione levels
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