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One of the mechanisms that are currently investigated is the Wnt signalling pathway

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Evans blue extravasation refers to the potential leakage of Evans blue dye from blood vessels into the surrounding tissues, which potentially indicates increased vascular permeability, possibly associated with inflammation

One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Sharma et al., 2010)

doi: 10.1007/s11356-016-8048-4 20 BhantanaP.RanaM

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