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These observations support growing evidence that semaglutide's effects extend beyond weight management and glucose control, while also highlighting that weight loss alone may not be an adequate surrogate for predicting cardiovascular benefit
10 Importantly, this suppression is not observed during daytime fasting when gut hormone secretion is reduced, 14 highlighting direct effects of peptide hormones on bone turnover in response to nutritional status
There is a reason effective GLP-1 medication costs more: it took billions in R&D, multi-year clinical trials, and FDA regulatory review to develop
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One of the most talked-about effects is known as "Ozempic Face" (Donnelly, 2024), which occurs when rapid weight loss leads to a loss of facial volume and sagging skin
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