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But its presence immediately begins breaking the peptide down

This can cause mechanical damage to the delicate peptide chains

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Individuals with this condition face substantially elevated risks of cardiovascular and chronic renal impairment, extrahepatic malignancies, and overall mortality [3-5]

TGR5 activity appears to not have been lost in type 2 diabetic humans whereby the infusion of CCK, or rectal taurocholate, causes GLP-1 and insulin release via the TGR5 axis in colonic L-cells and pancreatic -cells respectively (341, 342)

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