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Kooijman S, Wang Y, Parlevliet ET, Boon MR, Edelschaap D, Snaterse G, et al

A.ZavadilJ.LiK.et al (2012)

39 Most studies used B12 i.m., with slightly varying dosing regimens, commonly 1000 g daily for 57 days, followed by weekly injections for another 34 weeks, and then monthly injections

In practice, the long-acting GLP-1 RAs became preferred for general glycemic control due to convenience and greater A1c reduction, whereas short-acting ones like lixisenatide found a niche in combination products or for targeting post-meal glucose excursions (for instance, some use lixisenatide mainly to handle breakfast hyperglycemia)

But better is always subjective

Understanding how to reconstitute tirzepatide , knowing refrigeration requirements , and following correct storage duration guidelines protect the integrity of the compound