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They found higher expression of AA-selective cytosolic phospholipase A2 (CPLA2), COX-2, and membrane prostaglandin E synthase (mPGES) in the cortex of individuals with BD compared to controls [38]
Characterising how specific amino acid changes in variant receptors alter binding affinity, Gs coupling efficiency, cAMP signalling, and MITF activation in response to MC1R agonist stimulation
doi: 10.1016/j.fct.2025.115603 5 Pal SinghMPal KhaketTBajpaiVKAlfarrajSKimS-GChenLet al
Aged mice also exhibited elevated levels of the detrimental molecules spewed by senescent cells, called the SASP (senescence-associated secretory phenotype)
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