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These GLP-1 agonists now commonly referred to as anti-obesity drugs have been making large-scale trajectories in weight-loss results, and the need for such solutions has been so urgent

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however, the clinical significance remains uncertain

By combining peripheral effects (slower gastric emptying, metabolic adjustments) with central nervous system actions (reduced hunger and altered food reward), GLP-1 RAs produce sustained reductions in caloric intake and clinically meaningful weight loss