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Shaking creates froth and shear forces that can denature the protein, rendering it ineffective

People on GLP-1s were 37% more likely to develop alopecia than SGLT-2 users and 68% more likely than DPP-4 users

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Cardiorenal protection: potential of SGLT2 inhibitors and GLP-1 receptor agonists in the treatment of type 2 diabetes