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The positive rat result on CRF-induced corticosterone release (PMID 2995861) sits directly against the negative human result on CRH- and meal-induced ACTH and cortisol (PMID 7777652)
Appendix: Technical parameters For Research Use Only!
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Compared to subcutaneous injections, nasal sprays are non-invasive, painless, and easy to use, which supports frequent dosing
One human study found that 7 of 12 people with chronic knee pain experienced relief for over six months after receiving a single BPC-157 knee injection
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