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A responsible plan should include: medical supervision realistic goal-setting nutrition planning adequate protein resistance training or strength-focused movement hydration side-effect monitoring long-term maintenance planning emotional and behavioral support when needed Without that structure, people may lose weight but feel weak, undernourished, anxious about stopping, or unprepared for maintenance

Based on its findings, the EMA has advised updating prescribing information to list NAION as a very rare side effect

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For long-term benefits, regular maintenance may be recommended

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This review provides an integrative synthesis of current evidence on the multi-layered role of melatonin in aging, encompassing molecular, neurobiological, behavioral, and nutritional dimensions