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Thereafter, the read counts for each gene were used for determination of differentially expressed genes using the DESeq2 63 R package (v.1.16.1)

However, it also introduces variability in data quality

Significantly, as shown in Figure 6 in their Extended Data (9), Gordon et al

IGF-1 LR3 and Bone Health Insulin-like growth hormone is a critical mediator of bone health