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Preclinical data suggest GIP receptor engagement modulates lipid partitioning pathways and may act synergistically with GLP-1 receptor signalling in energy-balance models
More fatty acids can be transported for energy than is possible through either option alone
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The assessment of the homeostasis model also suggests an improvement in insulin sensitivity in type 2 diabetics treated with tirzepatide that is significantly greater than that seen with treatment with a selective GLP-1 receptor agonist
6 The use of GLP-1RAs is also associated with a lower risk of adverse cardiac events, such as myocardial infarction and stroke
Avoid leaving reconstituted peptides at room temperature longer than necessary, and return them to appropriate storage promptly after laboratory use
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