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Moreover, sitagliptin, at doses that inhibited systemic DPP-4 activity, reduced levels of plasma apoB48, without affecting plasma apoB100 concentrations, consistent with a reduction in intestinal TRL secretion (Figure 1, E and F)

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Therefore, it was considered that there are at least three possible pathways for the activation of sympathetic preganglionic neurons by exendin-4 under the present experimental conditions: a direct postsynaptic effect, an indirect effect via interneurons in the spinal cord, and descending excitation by bulbospinal (presympathetic) C1 area neurons in the medulla