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By modulating pro-inflammatory cytokines and their downstream signaling pathways, immunotherapeutic approaches can suppress osteoclast activation and restore the balance of bone remodeling, offering a promising strategy for treating chronic inflammation-related osteoporosis

These situations often involve ongoing low-grade inflammation, incomplete previous healing, and adaptive changes in how tissues function

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They explicitly conclude that blood should be centrifuged within the first 60 seconds to avoid early coagulation and compromised PRF structure