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One study, for instance, notes that people who are overweight or obese appear to have lower levels of vitamin B12 than those with a body mass index (BMI) that falls within the range considered to be normal. People who took vitamin B12 supplements of their own volition gained between 2.5 and 17 fewer pounds (1.27.7 kg) over ten years compared to those who did not take any form of supplementation with this vitamin

Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease

Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake [5] [6]

The advice is cautious and sensible rather than absolute

Healthcare providers use guidelines to decide the right dose and how often to give it

Real-world data shows that 70-80% of patients feel a significant energy surge within 24-72 hours