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Patients reporting persistent nausea beyond the 16-week titration period should have their PPI dose and indication reassessed, gastroparesis formally excluded, and semaglutide-related GI effects managed with dietary modifications (smaller meals, reduced fat intake) before attributing symptoms to a drug interaction

In a surgically induced-OA model in rats, liraglutide also attenuated rat cartilage degeneration through suppressing the release of inflammatory mediators and protected chondrocytes against endoplasmic reticulum (ER) stress and apoptosis induced by interleukin-1 (IL-1) or triglycerides [46]

Both peptides are generally well tolerated

Some studies have identified GLP-1 receptors in gallbladder tissue, potentially mediating effects on gallbladder motor function

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