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For clinicians, the message is clear: GLP-1s represent a powerful tool for slowing CKD progression and reducing cardiovascular risk but long-term success requires equipping patients to stay engaged with therapy for years, not months.

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It primarily drives fatty acid -oxidation within mitochondria and plays a significant role in maintaining metabolic flexibility

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However, data from the past 2 years suggest that real-world persistence on these drug classes is often suboptimal, with many people discontinuing these medications, even within their first year of therapy