In summary, this dual mechanism addresses the fundamental lipid dysregulation in MASLD by restoring the balance between lipid synthesis and degradation within the liver, thereby mitigating steatosis and its metabolic consequences (40, 43)
A study presented at ENDO 2025 looked at 120 postmenopausal women taking tirzepatide over 18 months
More recently, innovative molecules like the dual glucose-dependent insulinotropic polypeptide and the glucagon-like peptide 1 (GLP1R-GIPR) receptors agonists, such as tirzepatide, have shown even greater efficacy, with weight loss up to 18% [21]
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A person using insulin may also need closer attention to low blood sugar risk when other glucose-lowering therapies are involved