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Comparison revealed 136 genes consistently upregulated in DAMs across both models and timepoints, including well-established DAM markers such as Apoe , Lgals3 , and Spp1 (Fig

6a), with a concentration of approximately 1.5 times higher than cells treated with Ru(II)-OH and NP2 (Fig

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Pathway analysis of the EAE differential expression results showed strong induction of interferon signaling, Myc targets and metabolic shifts (Supplementary Fig

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