long term effects semaglutide complications from What are the long-term side of after 3+ years Safety & Side Effects Harvard and CDC study: Serious

Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM

Whereas much of the current attention surrounding GLP-1 RAs, or glucagon-like peptide-1 receptor agonists, has been focused on their unexpected and potent effect on weight loss, one important aspect of this class of drugs should not be overlooked: GLP-1 RAs have been shown to reduce the risk of heart attack, stroke, and other major adverse cardiovascular events (MACE) in patients with type 2 diabetes who have or are at high risk for atherosclerosis

STEP 1 figure is treatment policy estimand (ITT)

But its not a magic shield

Most people begin to notice subtle improvements in skin hydration and texture within 46 weeks of consistent supplementation

Insurance authorization for the switch may require documentation that semaglutide is no longer effective, which means your provider needs to note the plateau or inadequate response in your medical records