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Q: Why is fatigue not well-documented in GLP-1 clinical trials if so many patients report it

De Carvalho et al., 2017

Haas-Stapleton, E

While it is well-established that intestinal GLP-1 cells can exert influence through paracrine mechanisms, recent evidence suggests the possible existence of synaptic-like connections between GLP-1 cells and peripheral neurons, including those of the vagus nerve