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8 A growing body of evidence has shown that regeneration and maintenance of the cellular NADP(H) content is strongly implicated in a variety of pathological conditions, such as diabetes, cardiovascular disease, neurodegenerative diseases, aging, 4,5 especially in tumorigenesis and cancer progression

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While BW reduction likely contributes to improvements in conditions, such as hepatic steatosis or sleep apnea, GLP-1 RAs may also exert direct disease-specific effects, particularly through central mechanisms implicated in neurodegeneration and addiction [39]

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