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A 2024 meta-analysis published in the Journal of Sexual Health found that a combination of propionyl L-carnitine, acetyl L-carnitine (both available in oral supplement form), and sildenafil (Viagra) provided a significant benefit

The head-to-head SURMOUNT-5 trial, published in the New England Journal of Medicine in 2025, found tirzepatide produced about 20% body weight loss versus about 14% for semaglutide over 72 weeks

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