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Jin L, Jin F, Guo S et al (2022) Metformin inhibits NLR family pyrin domain containing 3 (NLRP)-relevant neuroinflammation via an adenosine-5-monophosphate-activated protein kinase (AMPK)-dependent pathway to alleviate early brain injury after subarachnoid hemorrhage in mice

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Bibcode:1981JBact.145..442A

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That distinction matters if you are dealing with fatigue, insulin resistance, stubborn weight gain, joint pain, elevated CRP, fatty liver, or the low-grade inflammatory state that often travels with metabolic dysfunction