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Obviously, it may be unclear which one of the parts of peptide + carrier complex would be responsible for the activity (for review, see Urist, 1996)

Common side effects are typically mild and transient: Pain, redness, or swelling at the injection site (most frequent) Mild diarrhoea or gastrointestinal upset Headache or dizziness shortly after administration Itching or mild skin reactions Temporary pink/red discolouration of urine These effects usually resolve within 2448 hours without intervention

Similarly, thioctic acid (10300 mg/kg) induced a graded antiallodynic response

Keep the container tightly closed at temperatures not exceeding 30C

Allergic reactions are extremely rare

This does not completely negate the peptide, but it reduces efficiency