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In the Phase 2 trial, starting at a lower dose (2 mg versus 4 mg) significantly reduced the incidence and severity of gastrointestinal adverse events without compromising weight-loss outcomes

Clotrimazole exerts its antifungal activity by altering cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane

Thus, lower levels of these metabolites in the starved urchin group would impair nucleotide synthesis, potentially leading to increased reliance on salvage pathways to maintain nucleotide pools

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