In order to improve fiber intake during a caloric deficit with reduced appetite, prioritizing the highest-fiber food sources (avocado, chia seeds, pears, berries, legumes) alongside fiber supplementation will help to mitigate the constipation experienced with GLP-1 agonists while supporting the therapeutic goal of satiety and blood glucose regulation
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To put Lillys 25.5% in perspective, previous pivotal trials for Tirzepatide, such as SURMOUNT-1 and SURMOUNT-5, showed weight loss of 20.9% and 20.2% respectively over 72 weeks
progressive cardiomyopathy, elevated creatine kinase, and skeletal myopathy in childhood
2026 Jan
I would frame these findings as hypothesis-generating and clinically important, but not definitive proof that GLP-1 therapy directly caused the reductions we observed, Sheer says