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Fetissov et al., 2002

Notably, Zepbound, approved in late 2023, has shown the fastest growth, with sales projected to more than double from last year, reaching $11.3 billion

Their shared activation of overlapping cellular pathways means the combined effect is not simply additive

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The early effects of GSTO1 inhibition by C1-27 (4 h treatment) predominantly involved induction of several stress-response-associated genes ( OSGIN1 , HMOX1 , SLC7A11 , DNAJB9 and so on) (Supplementary Table 14)