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An alternative strategy is based on targeting tumor necrosis factor alpha (TNF-), a pro-inflammatory cytokine that has increased levels in AD

These combined actions of GLP-1R signaling cause improvements in glycemic control as well as weight loss in type II diabetes (T2DM) patients treated with GLP-1R agonists

This dual mechanism explains why tirzepatide users often see lipid improvements that exceed what diet and exercise alone produce at comparable weight loss levels

Tirzepatide offers them a science-backed option to help manage appetite, improve metabolism, and cut down harmful fat

10.1016/j.brainres.2009.05.025 63

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