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The 28-week, phase three, Evaluate Efficacy and Safety of Exenatide Once Weekly and Dapagliflozin Versus Exenatide and Dapagliflozin Matching Placebo (DURATION-8) trial demonstrated that dual therapy with dapagliflozin and exenatide had additive effects on lowering weight and blood pressure, though with a less than additive effect on HbA1c [102]
They reduce pathological drug and alcohol craving by normalizing dysregulated reward circuitry rather than suppressing it globally
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