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Importantly, elevated KYNA in the CNS may contribute to cognitive deficits in schizophrenia by antagonizing 7nAChRs and NMDARs, which are critical for synaptic plasticity, working memory, and cortical network coordination [76, 240,241,242]
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Those taking calcium supplements had a 3.8% reduced risk of death
Currently approved treatments such as tetrabenazine and deutetrabenazine target only chorea and offer symptomatic relief without altering disease progression
Combination of Direct and Indirect Evidence in Mixed Treatment Comparisons
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