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Future studies should explore whether perioperative hydration protocols, electrolyte monitoring, or cardiovascular screening could help mitigate these risks while maximizing the benefits of GLP-1 agonists in orthopedic surgical populations

By promoting glucosuria and reducing hyperglycaemia, SGLT2 inhibitors dampened glucotoxicity, which indirectly resulted in an improvement of -cell function and peripheral insulin sensitivity [12]

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After this, the cells were exposed to heat shock at 42 C for 1 h

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