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Any treatmentwhether a supplement, medication, procedure, injection, therapy, or devicecarries potential risks, especially when used in excess or by individuals with certain medical conditions or genetic predispositions

Visiting a doctor will help pick a treatment plan

doi:10.1186/s12933-018-0800-2 Garvey WT, Batterham RL, Bhatta M, et al

Diet and exercise Although GLP-1 Medication helps curb appetite, a balanced diet and regular physical activity will enhance results

Triple agonists add glucagon receptor activation, which: Increases resting energy expenditure by 8% to 12% (Jall et al., Diabetes Care 2024) Promotes hepatic fat oxidation and reduces steatosis May offset some of the lean mass loss seen with GLP-1 monotherapy (early signal, not yet confirmed in long-term trials) The weight loss ceiling for retatrutide appears to be 24% to 26% based on phase 3 data, though long-term real-world outcomes are not yet available

A muscular athlete with a BMI of 28 and no metabolic issues likely does not need GLP-1 therapy