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A randomized controlled trial of chronic pain from osteoarthritis in adults found similar benefit from acetaminophen and ibuprofen.[23] However, a randomized controlled trial of acute musculoskeletal pain in children found that the standard OTC dose of ibuprofen (400 mg) gives greater relief of pain than the standard dose of paracetamol (1000 mg).[24] In recommended doses, paracetamol does not irritate the lining of the stomach, affect blood coagulation as much as NSAIDs, or affect function of the kidneys

PMID: 2838549

At a normal therapeutic dose, acetaminophen is primarily metabolized by the liver to sulfate and glucuronide conjugates, while a SMALL amount is metabolized by CYP2E1 to a highly reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI)

Ann Anat 177: 431-438, 1995

Oral ingestion of both concentrations of collagen peptides increased the water content of the SC and decreased TEWL

Research suggests glutathione may help buffer oxidative stress in Hashimoto's thyroiditis, where TPO antibodies drive inflammation