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In a seminal March 2021 New England Journal of Medicine study, adults receiving a weekly 2.4 mg injection of semaglutide for about 15 months lost 15% of their body weight35 pounds, on averagecompared to just 2.4% body weight loss in the placebo group
The program established a favorable safety profile but the Phase IIb endpoint did not differentiate sufficiently from placebo to support continued development for obesity
Key Comparison: A 120 lb woman who drinks 2 standard drinks reaches approximately 0.08% BAC the US legal driving limit
With 476,857 individuals across 18 different countries (propensity score matched 1:1 with pregnant controls), this is the largest study to date in this historically underserved population
Published online December 20, 2005 Muscle Nerve 1991
other investigations have shown that LFC reduction associated with metabolic disorder improvement and a relative decrease of 30% combined with an improvement in ALT may be predictive of a more active histological response
