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Description About FOX04-DRI (Proxofim) Anti-Aging & Longevity, Targeted Senolytic Action, Age-Related Diseases Peptide FOX04-DRI (often written FOXO4-DRI

Subsequent studies have consistently supported the finding of widespread RCD, activated via the intrinsic apoptotic pathway, which includes concurrent elevation of capsase-9, cytochrome C, BAX, and a decrease in anti-apoptotic BCL2, in rat (63, 85, 89, 114, 116, 125, 134, 138142), mouse (62, 113, 117, 143) and NHP (137, 144147) models, with both in vitro (62, 85, 113, 114, 116, 139, 140) and in vivo (62, 63, 116, 117, 125, 134, 138, 141143) experimental protocols

All quantitative safety findings derive from animal and in-vitro models

Statements Author contributions MS, MP, and DC contributed to the conception and design of the review

25 , 11471159.e10 (2017)

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