The National Institutes of Health Office of Dietary Supplements has not set a Tolerable Upper Intake Level for B12 precisely because no reliable evidence of harm from high intakes has been established in healthy people
However, hundreds of millions of Americans who do consume B12 may also be at risk because of conditions that could be hampering their bodys absorption of B12
For the most effective dosage and administration method for your body, it is necessary to consult with a healthcare professional
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THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption
On top of that, proper function of the folate cycle is also required for synthesizing and regenerating a cofactor needed for the production of neurotransmitters (serotonin, melatonin, dopamine, noradrenaline, adrenaline) and nitric oxide