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According to a study published in Clinical Pharmacology in Drug Development, taking it with less water or a slower tablet breakdown in the stomach results in higher blood levels, while taking it with food can lower absorption
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Phytomedicine 15(12):10321037
Clinical pharmacology review: Rybelsus (semaglutide) tablets
Patients with a history of gastroparesis, severe gastrointestinal disease, or inflammatory bowel disease require careful evaluation, as delayed gastric emptying induced by semaglutide may potentially worsen symptoms or interfere with the absorption of other medications
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