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The most common side effects are digestive, such as nausea, bloating, or a change in bowel habits

Taking semaglutide was associated with approximately a 11% higher absolute risk of preterm birth

Some of these drugs are modified natural peptides, some fully synthetic peptides, others small molecules, and one product combines an antibody with a peptide. Yet GLP-1 medicines are the key driver in the peptide market

Research shows that GLP-1 medications, especially when combined with standard blood pressure medications, can help people with resistant hypertension finally get their numbers under control

Direct nutrient stimulation may induce the initial release of GLP-1 from small intestinal EECs, while large intestinal EECs likely release GLP-1 via a neural hormonal reflex or from microbe-derived metabolites, although this remains to be explored 93,99 (see the Gut microbiotabrain connection section)

"The need for alternative GLP-1 benefit in design solutions is underappreciated and we believe this could represent a significant opportunity