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Nguyen says to watch for the following gastrointestinal side effects: Nausea and vomiting may result from slower digestion (delayed gastric emptying) and increased fullness, especially when first beginning the medication
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Additionally, metabolic adaptationsometimes called adaptive thermogenesiscan occur, where the body becomes more efficient at conserving energy in response to sustained caloric restriction
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Retatrutide : Phase 2 completed for obesity (NEJM 2023, 338 patients) and Phase 2a for MASH
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