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The short-term performance gains are more modest, the lingering long-term unknowns around muscle integrity, bone health, and weight rebound are more consequential
Plateau after initial success is normal, not a signal to change course
For example, in the SURPASS-2 study, TZP at the dose of 5, 10, and 15 mg reduced HbA1c by -2.18% vs -1.86% with semaglutide and weight by -9.3 kg vs -5.7 kg
Avendano, who work in the functional medicine space, have a battle-tested protocol for patients using GLP-1 drugs without sacrificing muscle
Together, they may offer synergistic benefits that neither provides alone