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Renal OCTN2 expression and activity increase when the carnitine concentration is reduced in the plasma and/or glomerular filtrate, whereas OCTN2 mRNA expression levels remain unchanged in the gut, liver, or skeletal muscle [254], highlighting the central role of the kidney in maintaining carnitine homeostasis

All morning doses of the study treatments were taken with 120 mL of water after an overnight fast ( 6 h and with no fluid intake within the 2 h before dosing), followed by post-dose fasting for 30 min

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Goal: modest fat loss as an adjunct Two compatible strategies: 1) Pair precardio dosing (1 to 2 grams 30 to 60 minutes before sessions) with a calorieconscious diet and consistent training