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Notably, FSP1 can also reduce vitamin K and its derivatives, which share a quinone backbone similar to that of CoQ 10 15,82
Retinol and copper peptides serve completely different purposes here
110 Mechanistic studies have shown that combination therapy induces increased ROS and lipid peroxides and depletion of GSH, and downregulates ferroptosis inhibitory proteins, including FTH1, SLC7A11, GPX4, and FPN, 110 suggesting that -elemene is a novel inducer of ferroptosis
And the honest answer is: we think so, but we do not know for certain
By shedding light on this often-overlooked side effect, we hope to equip patients and healthcare providers with the knowledge necessary to manage and mitigate these risks effectively
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