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Lidocaine is extensively metabolized in the liver, so drugs that decrease hepatic blood flow (e.g., propranolol) or inhibit CYP1A2/CYP3A4 (e.g., fluvoxamine, ketoconazole, clarithromycin) may elevate systemic concentrations and increase the risk of central nervous system or cardiovascular toxicity

11 : 331335 DeLisle RC, Williams JA

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When you eat, the hormone triggers the production of insulin and sends your brain signals that youre full