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L.ReimannF.et al (2019)
Therapeutics and Clinical Risk Management, 7 , 377385
Nonetheless, some commercial mimics of GLP-1, such as Liraglutide, even when administered peripherally, appear to cross the BBB and activate neurons within the ARC resulting in GABA dependent inhibition of neuropeptide Y (NPY) and agouti-related peptide (AgRP) secretion
Taken together, all these results indicate that the newly identified spherical vesicles, with diameters ranging from approximately 3050 nm, may serve in plant retrograde transport and are distinct from the tubular recycling endosomes described in animal systems
As a GLP-1 receptor agonist, it regulates appetite and improves blood sugar control, making it suitable for those with obesity or related health issues
Current evidence from randomised controlled trials, meta-analyses, and real-world studies indicates no consistent or causal relationship between these agents and serious GI side effects
