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Lead compounds can be optimized through principles such as bioisosterism, prodrugs, quantitative structure-activity relationships (QSAR), and 3D-QSAR, followed by in silico ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) prediction and physiologically-based pharmacokinetic simulations for preclinical testing
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Unlike heart disease or diabetes, fatty liver stays silent for decades
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The gradient was 0 min, 100% B
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