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The multi-shell structure-based smart nanoplatform (HMCPIM9P) incorporates multiple functional nanoparticles that synergistically deliver cisplatin, photosensitizers, and immune activators to tumor cells

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(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates